This work describes the development of a gastroresistant antimicrobial formulation\ncomposed of two carriers, pectin and liposomes, intended to improve the effciency of norfloxacin\n(NOR) against multi-resistant bacterial strains. The formulations showed physicochemical stability\nfor 180 days (4 C) in terms of size, polydispersity, and zeta potential of the vesicles, prolonging the\nin vitro release of NOR for 11 h. The hybrid nanocarriers improved the in vitro antimicrobial activity\nagainst different multidrug-resistant bacterial strains, such as Salmonella sp., Pseudomonas aeruginosa,\nE. coli and Campylobacter jejuni, in comparison to commercial NOR and liposomal suspensions.\nThe in vivo toxicity assay in chicken embryos revealed that the hybrid systems were not toxic in\nany of the different parameters analyzed, a result also corroborated by the analyses of biochemical\nbiomarkers of the chicken-embryos liver function.
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